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Light Line™ Urology

Light Line™ Urology

Between 15-25% of hospitalized patients have a urinary catheter placed during treatment, putting them at risk for a catheter-associated urinary tract infection (CAUTI) [2]. In fact, depending on location, patients can expect to have a catheter anywhere between 3-90% of their days at the hospital [3]. CAUTIs are one of the most common HAIs, with an estimated 93,000 occurrences in acute care settings and over 900,000 total across all hospitals and nursing homes. [1]. There are between 1.4 and 4.8 CAUTIs per 1,000 catheter days [3]. As much as 10% of the 215 million annual worldwide urological users have reported CAUTIs [4] [5]. Developing countries have infection rates often as high as 5 times higher than developed countries. Unlike other HAIs, CAUTI rates have not declined since 2008, making innovations that can decrease that rate particularly attractive [6]. 

The population at risk for CAUTIs is the largest at risk of any HAI (Table 2. [7]). CAUTIs result from bacteria colonizing catheters while they reside in the body, eventually infecting the bladder, kidneys, or bloodstream. The catheters and collection bags can contain large numbers of undetected drug-resistant microorganisms in close proximity to the patient, acting as reservoirs for pathogens that can result in more serious and costly HAIs [8]. Current externally applied pharmacologic disinfection through introduction of antibiotics or antiseptics has very poor clinical efficacy. This is in part due to biofilm formation and antibiotic resistant strains of bacteria. Because this problem remains unsolved with current products, infection rates and associated healthcare costs continue to rise. Though antibiotic-resistant strains of bacteria become more common each year, the pace of approval of new antibiotics has dramatically slowed. The problem of drug resistant infections will continue to grow and is best addressed with a solution that is independent of microbial antibiotic resistance mechanisms. 

References

  1.  S. S. Magill, J. R. Edwards, W. Bamberg, Z. G. Beldavs, G. Dumyati, M. A. Kainer, R. Lynfield, M. Maloney, L. McAllister-Hollod, J. Nadle, S. M. Ray, D. L. Thompson, L. E. Wilson and S. K. Fridkin, "Multistate point-prevalence survey of health care-associated infections," N Engl J Med, vol. 370, no. 13, pp. 1198-208, 2014. 
  2. M. J. Hall, C. J. DeFrances, S. N. Williams, A. Golosinskiy and A. Schwartzman, "National Hospital Discharge Survey: 2007 summary," Natl Health Stat Report, no. 29, pp. 1-20,24, 2010. 
  3. M. A. Dudeck, J. R. Edwards, K. Allen-Bridson, C. Gross, P. J. Malpiedi, K. D. Peterson, D. A. Pollock, L. M. Weiner and D. M. Sievert, "National Healthcare Safety Network report, data summary for 2013, Device-associated Module," Am J Infect Control, pp. 206-21, 2015. 
  4. M. Maclean, S. J. Macgregor, J. G. Anderson, G. A. Woolsey, J. E. Coia, K. Hamilton, I. Taggart, S. B. Watson, B. Thakker and G. Gettinby, "Environmental decontamination of a hospital isolation room using high-intensity narrow-spectrum light," J Hosp Infect, vol. 76, no. 3, pp. 247-51, 2010. 
  5. J. Evans, "The World Market for Catheters: A Kalorama Information Market Intelligence Report," Kalorama Information, 2015.
  6. "2014 National and State Healthcare-Associated Infections Progress Report," Centers for Disease Control and Prevention, Atlanta, 2016.
  7. E. Zimlichman, D. Henderson, O. Tamir and a. et., "Health Care–Associated Infections: A Meta-analysis of Costs and Financial Impact on the US Health Care System," JAMA Intern Medicine, vol. 173, no. 22, pp. 2039-2046, 2013. 
  8. P. Tambyah, V. Knasinski and D. Maki, "The direct costs of nosocomial catheter-associated urinary tract infection in the era of managed care," Infect Control Hosp Epidemiol, vol. 23, no. 1, pp. 27-31, 2002.